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If it does not, the most defensible general approach is cold-chain handling: freezer storage for long-term dry powder, refrigerator storage for short-term reconstituted solution, and no casual room-temperature storage after mixing

Call 999 or attend an emergency department immediately if experiencing symptoms of anaphylaxis (difficulty breathing, severe rash, swelling of face/throat, feeling faint)

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You are experiencing unexplained symptoms like fatigue, nausea, dizziness, or skin changes

Thinning skin, vasculitis, purpuric dermatosis, platelet deficiency, liver disease, vitamin K deficiency, vitamin C deficiency, moving your body during the injection, or dehydration may also cause bruising