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Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

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Elevated NAD+ in adipocytes (fat cells) has been linked to increased mitochondrial respiration and enhanced lipolysis (fat breakdown), all without directly impacting appetite or central nervous system activity in the same way some other compounds might

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What works in a petri dish doesn't always translate directly to a complex organism, and topical application has different considerations than systemic delivery