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The patent gives exceedingly little information about the isolation process, stating only that a variety of relatively crude chromatographic approaches were utilized (i.e., ion-exchange and gel) followed by dialysis (i.e

Casellas-Vidal, D., et al

Dihexa peptide can promote the renewal of neck skin cells and the synthesis of collagen, enhancing the elasticity and firmness of neck skin

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these include increased metabolic flexibility, uptake of extracellular amino acids via compensatory transporters and macropinocytosis, and expression of nutrient stress-response proteins (Fig