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In biochemical and cellular research systems, L-glutathione is widely used as a reference compound for studying oxidative stress, redox signalling, enzymatic detoxification pathways, and glutathione-dependent enzyme activity

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The HBOT SPECT brain blood flow and associated clinical improvements may have resulted, in part, from Nrf2-induced increases in astrocyte GSH

In addition, exposure to exogenous hydrogen peroxide can activate iron response elements involved in the regulation of iron metabolism by binding to mRNA, which can inhibit the translation of ferritin and reduce ferritin synthesis, thus increasing the concentration of free iron in cells