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Clinical experience with semaglutide and tirzepatide shows weight typically returns after discontinuation, which supports long-term use
This applies equally in the Cagrilintide vs Retatrutide context, as both peptides require careful ramping
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al
On the other hand, pioglitazone in the PROactive study [47], in patients with type 2 diabetes with symptomatic vascular disease, did not demonstrate a reduction in the risk of stroke, but in a post-analysis in patients with previous stroke it demonstrated a significant reduction in recurrence
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