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A polymorphism in the methionine synthase reductase (MTRR) enzyme, responsible for maintaining adequate levels of cob(III)alamin, is known contribute to a moderate increase in Hcy levels (Gaughan et al., 2001)

Weight loss and triglyceride reduction create a positive feedback loop

However, until it receives regulatory approval from the MHRA or EMA, it cannot be recommended for use outside of clinical trials

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Differential gene expression between mc2r KO and WT was assessed through pairwise comparisons via the exactTest function from edgeR, and p values were adjusted with the decideTest function according to the BenjaminiHochberg correction method