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Long-term follow-up studies are needed to assess durability of therapeutic effects and to identify any delayed adverse effects or complications that might not be apparent in shorter-term investigations
Higher starting doses do not accelerate results and typically increase nausea, vomiting, or constipation that actually delays adherence and slows progress
GIP has also been found to exert influence over other tissues such as bone, although its extraglycemic profile is quite limited and largely pre-clinical in nature compared to its much celebrated partner GLP-1 [13]
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