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A Cochrane review found that melatonin taken close to destination bedtime reduced jet lag symptoms after long-haul travel [5]
They are commonly used to address nutrient deficiencies, chronic fatigue, a sluggish metabolism, and even mood imbalances
As a highly permeable molecule capable of crossing cellular and mitochondrial membranes, melatonin effectively scavenges reactive oxygen and nitrogen species and modulates the activity of pro-inflammatory cytokines (Srinivasan et al., 2010)
Another study found that B12 deficiency in pregnant women was associated with higher body fat percentages in their children[1], suggesting a role in long-term metabolic regulation
Notably, these studies also established that the mode of administration (IP versus oral) did not influence the radio-mitigative activity of DSePA against RP
