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The 50100mg daily dose range was derived from rodent models where 10mg/kg bodyweight produced measurable NNMT suppression without toxicity across 12-week administration periods

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Similarly, long-term monthly fipronil administration has been selected for resistant flea strains, and resistant heartworm-causing Dirofilaria immitis populations have developed, undermining previously effective therapeutic approaches (23)

As a result, theres not enough IF to absorb B12