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PACS2/CPT1A/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy

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Cpt1a ablation induces oxidative stress and associated responses in ErbB2+ breast cancer cells An additional consequence of increased NAD + /NADH and NADP + /NADPH ratios is redox imbalance, which can lead to oxidative stress and associated oxidative damage to macromolecules including DNA, lipids, and proteins resulting in cell death 43,44

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