It is currently in a phase-3 trial, which is set to finish by early 2026
Additionally, patients should be advised to apply a small amount of the cream to a test area of skin before widespread use to ensure they do not experience an adverse reaction
Limitations of this study included the predominantly white demographic, which may potentially limit the generalizability of the results to more diverse populations
GillTWatlingSERichardsonJDMcCluskeyTTongJMeyerJHet al
This included treatment-emerging depression, exacerbation of depressive symptoms, fluctuations in depressive mood, and other clinically pertinent depressive-related events expressly covered in the studies.Considering the possible expanded effect of the GLP-1 RAs in mood and the central nervous system, the secondary outcomes were anxiety, mood disorder, suicidal thoughts, and mood-related adverse events.To increase the comparability and exhaustiveness of our analysis and investigate possible mediating variables about psychiatric adverse events, we also released data about metabolic parameters including body weight, BMI, fasting blood glucose, and lipid profiles