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I don't see [GLP-1 agonists] as being any different than other medicine that we use to treat chronic conditions like atherosclerotic heart disease. While the data are not clear about the maintenance of CV benefits in those going off GLP-1 agents, data from mixed diet and lifestyle intervention studies, for example, do suggest that the cardiometabolic benefits of the lost weight may persist out to 5 years, even if some is regained

Though Ozempic and Wegovy have fast become household names, many are still unaware that these drugs have their origins in university research

Step 2: Provider Review

The STEP clinical trials showed that weight loss on semaglutide 2.4 mg typically begins to plateau around week 60

The real mechanism is transient inflammation from active ingredients that accelerate cell turnover, based on dermatology research dating to Kligman 1972 and updated in 2025