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For example, tirzepatide (sold under the brand name Zepbound) targets two receptors, and clinical trials suggest it helps people lose more weight than semaglutide (the active ingredient in Wegovy), which only targets one
Additionally, activated microglia are implicated in barrier breakdown, further exacerbating MS pathology [146]
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Those patients who have a history of pancreatitis, gallbladder disease, or kidney problems may not be eligible for semaglutide GLP-1 injections
Combined with the weight loss effects, this could position retatrutide as a comprehensive metabolic treatment
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