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The "90% oral bioavailability" claim is unsubstantiated
Protein binding is concentration-dependent and influenced by -1-acid glycoprotein concentrations, factors that may vary markedly in trauma, sepsis, pregnancy, and chronic disease
As a result, many experts recommend that people taking metformin regularly get screened for vitamin B12 deficiency
Cancer Immunol Res (2020) 8(8):1099111
Staying well-hydrated helps
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