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The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia)

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Lyophilization (freeze-drying): Preserves integrity and extends shelf life

Acneiform or skin changes have been reported with high-dose or frequent B12 administration, though the mechanism remains unclear