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Stress boosts oxidative stress, which depletes glutathione and impairs antioxidant defenses

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Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-lepr(fa)) rat

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It argues that the failures of EVOKE and Exenatide-PD3 narrow the hypothesis rather than refute it, pointing toward brain-penetrant compounds, biomarker-anchored endpoints, and patients selected by biology rather than diagnosis