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Chronic administration of GLP1/E significantly improved also glucose handling, as compared with the vehicle-treated PWA group, whereas no glucoregulatory actions were detected in mice treated with the dual or triple agonist (Fig
Faust JS (2024)
Greater growth hormone output
GCG stimulates hepatic glucose production, leading to hyperglycemia
But the rationale is sound: GLP-1 receptors exist on a continuum of activation, and partial activation may produce partial benefits with fewer side effects
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