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Repeated injections into the same spot cause scar tissue and lipohypertrophy, both of which reduce B12 absorption over time
BPC-157 acts locally at the injury site, upregulating VEGFR2 and stabilizing nitric oxide signaling, while TB-500 works systemically, binding G-actin to recruit repair cells throughout the body rather than only where it is injected
Gene Expression Modulation (the "4,192 genes" data point) The Broad Institute Connectivity Map analysis is the single most-cited modern data point on GHK
Factors affecting results Individual variation is significant
The research is especially robust for conditions like tennis elbow, rotator cuff injuries, and Achilles tendinopathy
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