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In the transcription factor pathway, H 2 O 2 regulates the activity of transcription factors, including NF-B, AP-1, HIF-1, and FOXO3 [82, 83], altering gene expression and promoting apoptosis

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Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or to establish a causal relationship to drug exposure

Touati, G., Prieur, A