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Among the various hypotheses that have been proposed for the pathophysiology of ASD, alterations in excitatory and inhibitory neurotransmission states have been prominently implicated [2, 3]

Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al

At the same time, melatonin treatment significantly inhibited the oxaliplatin-induced increase in the mRNA expression of cytokines such as interleukin-1 (IL-1), tumor necrosis factor- (TNF-), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1) in the spinal dorsal horn [48]

BBB impairment is one of the well-established pathological features of TBI (102106)

I have found that methylation support seems to really help me with this