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Silibinin was found to improve conditions by multiple mechanisms of action including by reducing insulin resistance and lowering reactive oxygen species
Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes
The compound is described in the literature as pleiotropic: its downstream effects engage multiple biological systems simultaneously, and its primary binding receptor has not yet been identified
Moeller et al
GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter
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