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however, the authors found a potentially smaller clinical effect with drugs based on exendin-4 (exenatide and lixisenatide) compared with those more structurally similar to native GLP-1 (albiglutide, dulaglutide, liraglutide, and semaglutide)

Another recent study points out that genetics can influence as much as 50% of a persons propensity to gain weight and difficulty losing it, with the other 50% coming from environmental factors like diet and exercise.2 So, it makes sense that the medical establishment is finally embracing weight loss drugs as more than just a cosmetic concern

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In Phase 3 clinical trials, retatrutide has been studied as a once-weekly injection, starting at 2mg once weekly and increasing gradually every four weeks