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In the 52-week SURPASS-4 trial TZP was tested versus insulin glargine in diabetic adults and a high CV risk below not sufficient GC at baseline and in therapy with one to three oral glucose-lowering drugs (metformin, sulfonylurea, SGLT2-i)
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Notably, while deletion of GLP-1Rs in WNT1-expressing neurons does not affect basal food intake and body weight, the acute appetitesuppressing effects of exendin-4 and chronic weightlowering effects of dulaglutide are diminished [35]
Many patients achieve excellent results at lower maintenance doses without advancing to 2.4 mg weekly
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