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10.1210/er.2004-0001 35 JiangJ.ChangX.NieY.ShenY.LiangX.PengY.et al (2021)
Efficacy: the biggest uncertainty One of the biggest unanswered questions around oral GLP-1s is not convenience or appeal, but effectiveness
In early clinical trials, patients on GLP-1 agonists have achieved weight loss of 1520%, compared to the 510% typically seen with previous medications. Holistic approach to GLP-1 drugs Beyond weight loss, GLP-1 agonists have demonstrated the ability to reduce major cardiovascular events, combat fatty liver disease and alleviate obesity-related complications such as knee pain, sleep apnea, and acid reflux
W., Bagan, J
Thus, by increasing GIP and PPAR levels, P5 chronic treatment may restore GIP/GIP-R signalling in adipocytes
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