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The results are consistently positive and the mechanistic data is compelling, but as of 2026 there are no completed Phase 3 human randomized controlled trials
Additionally, approximately 20.9% of retatrutide users at 12 mg experienced dysesthesia (skin sensitivity/tingling), a side effect not seen with tirzepatide
Therefore, in practical applications, it is necessary to strengthen data security protection measures and ensure the fairness and transparency of AI systems
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