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In studies comparing insulin administration with once weekly GLP-1RA, including albiglutide and exenatide, local site reactions were more common with GLP-1RA (~10%), compared with 15% with insulin (95)

Aunque es cierto que se ha sugerido que estos edulcorantes contribuyen a reducir la ingesta calrica diaria, cuando sustituyen las versiones azucaradas, existe cierta preocupacin y debate sobre si su sabor dulce puede ser capaz de activar los receptores dulces de la lengua y de esta forma aumentar el apetito y la ingesta de alimentos, especialmente aquellos ricos en energa

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