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The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPAR
An earlier study of an unmodified synthetic hGH 177191 sequence reported an antilipogenic effect in rat adipose tissue but did not detect a significant lipolytic effect by glycerol release under the tested conditions
Specifically, it represents the C-terminal fragment of HGH (residues 176-191), the precise portion of the molecule that handles fat metabolism, with an added disulfide bridge for stability
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