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While preclinical studies have suggested potential mechanisms by which GIP receptor activation might influence adipose tissue metabolism or mitochondrial function, human data have not demonstrated a meaningful increase in basal metabolic rate with tirzepatide

You can read the abstract at Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial Among people who are overweight or obese, it is well established that weight loss can reduce cardiometabolic risk factors

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If you hit a semaglutide plateau where weight loss stalls, do not assume the medication has stopped working