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Corticosterone in drinking water: altered kinetics of a single oral dose of corticosterone and concentrations of plasma sodium, albumin, globulin, and total protein
Amsterdam, Netherlands
As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]
doi: 10.1038/sj.bjp.0706912 123 BrhlHCihakJPlachJKunz-SchughartLNiedermeierMDenzelAet al
During a September 22 analyst call, Pfizer Chief Strategy and Innovation Officer and Executive Vice President Andrew Baum said: Differentiated science and scalable platforms with potent and durable peptides that may enable tenfold lower doses than some approved products for a very attractive cost of goods
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