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Early onset cancers are rising, with higher volumes of patients ages 45 and younger for breast (+6.6%), colon (+10.0%), kidney (+2.1%) and uterine (+16.0%) cancers from Q4 2018 to Q4 2023 (p

A 2007 double-blind, multicenter trial (n=102) showed ALC 1,500 mg/day significantly improved tender point count, total myalgic score, depression, and musculoskeletal pain compared to placebo.[9] A 2015 RCT found ALC 1,500 mg/day comparable to duloxetine 60 mg/day for pain and depression.[8] Most notably, a 2023 RCT demonstrated that adding PEA 1,200 mg/day + ALC 2,000 mg/day to ongoing duloxetine + pregabalin therapy produced significantly greater improvements in Widespread Pain Index, FIQR, and FASmod scores.[7] Role in Treatment: ALC can be used as monotherapy or adjunctive therapy in fibromyalgia

Chronic lesionsfocal, multifocal, to diffuse may include inflammatory cell foci, hepatocytomegaly, oval cell hyperplasia, and cholangitis

however, continuous GLP1-RA versus DPP4i use was associated with a 21% lower risk (HR 0.79, 95% CI 0.640.97

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