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These findings underscore the need for enhanced patient-clinician communication about cancer risks associated with GLP-1 medications, the authors wrote

Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g

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Some find it improves over time