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Several reasons may explain the observation that the mean treatment difference was 12.5% in STEP 1 and 8.7% in SELECT

"I think that I have maybe an unhealthy relationship with weight and food because of the industry that Im in but I dont think that I have an eating disorder."

Orforglipron: First Oral Non-Peptide GLP-1 Agonist Orforglipron is a non-peptide, small-molecule GLP-1 receptor agonist with a molecular weight of 541.65 Da, developed by Eli Lilly

But the same mechanisms that make these drugs effective can also cause gastrointestinal side effects such as: Nausea Vomiting Diarrhea Reduced appetite All of these symptoms can contribute to lower fluid intakeor increased fluid losswhich is a fast track to dehydration