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The practical implication is that secretagogues work within the body's own feedback loops
Free radical pathology and antioxidant defense in schizophrenia: a review
demonstrated that knockdown of eNOS induced endothelial cell metastasis and proliferation through activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT (protein kinase B, the key downstream target protein of PI3K) pathway, and inhibited the formation of tubular structures in vitro , confirming that eNOS regulates endothelial function by inversely controlling the proliferation and migration of endothelial cells as well as by directly regulating their tube-forming potential (57)
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