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3 main reasons These are the top reasons people quit GLP-1s, Hill says

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Paradoxically, work with polar bodies from endometriosis patients indicates increased rates of aneuploidy in patients with endometriosis, with statistically larger sample sizes needed to authenticate this conclusion, while definitive data demonstrate that embryos from endometriosis patients do not (147, 148)

The short answer: it depends but a reasonable expectation is: At 4 weeks : subtle internal changes and gentle lightening At 8 weeks : more visible brightening and evenness At 12 weeks : notable improvements in tone, radiance, and pigmentation Keep in mind that studies show positive changes in glutathione levels and skin brightness over 412 weeks