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In line with the well-documented incompatibility between animal experiments and human trials (209, 307, 308), current evidence from systematic reviews identified significant limitations in preclinical animal research, encompassing both the quality of publications and translational value (209, 210)

doi:10.1016/j.diabres.2010.02.017 Zhong J, Kankanala S, Rajagopalan S

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Last June, a study led by Jastreboff reported weight declines never before seen with a single drug