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Do not flush medications down the toilet or pour them into a drain unless instructed to do so

The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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Who should avoid this combination Individuals with a history of thyroid cancer or MEN 2 syndrome should not use tirzepatide, and therefore should not use this combination