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Patients were on a stable dose of insulin prior to enrollment with no changes in insulin dose permitted during the run-in period

is funded by NIH NIDDK R01DK122167

Writing in Food Research International , the international team of researchers not that extracts from mat and guayusa may activate TGR5, which they describe as a nuclear receptor of relevance for the prevention and management of diabetes and metabolic syndrome because of its involvement in the regulation of energy expenditure and insulin sensitivity