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Previous medications like Semaglutide (Wegovy/Ozempic) target only GLP-1, while Tirzepatide (Mounjaro/Zepbound) targets GLP-1 and GIP
BONUS TIPS COACH GLENN: If you try Wegovy, see it as a reset button, not the solution
Semaglutide is a GLP-1 receptor agonist that helps regulate appetite and food intake
Up-regulation of mGlu2 receptors was observed in cultured DRG neurons isolated from 30-day acetyl-l-carnitine-treated -GalA knockout mice, which was no longer detectable in DRG neurons isolated 30 days after the end of treatment, hinting at an additional mechanism being responsible for the long-term analgesic effect [35]
By Rick Tague, M.D., M.P.H
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