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In addition, during vaso-occlusive episodes, SCD patients show distinct metabolite profiles from those at steady-state 7,8,9,10

1.7% in placebo group) Real-World Translation For context, losing 5-10% of your body weight produces significant health improvements, including better blood sugar control, reduced blood pressure, improved cholesterol levels, and decreased joint pain

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Although individuals with obesity often exhibit greater muscle mass compared to those with normal body weight, their muscle quality is generally lower due to factors such as relative weakness and reduced mobility [15, 96]