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The dosages and protocols discussed here are general references from published studies and experimental reports, not individualized prescriptions

Drug Interactions Other Medications and Supplements Lipotropic agents and high-dose B12 may interact with certain prescription drugs (e.g., levodopa, methotrexate) or other supplements

It could be anything, from bad nutrition habits to co-morbidities: Lower serum vitamin B12 levels have been related to adverse metabolic health profiles, including adiposity

Sosne G, Qiu P, Kurpakus-Wheater M

Methylcobalamin is used primarily in your liver, brain and nervous system, in fact methylcobalamin is the specific form of B12 needed for nervous system health