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doi:10.1016/S0140-6736(14)61682-2
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Biocentury www.biocentury.com/article/36923/amylin-takeda-discontinue-davalintide (2010)
Obesity is a chronic condition, and patients may benefit from taking GLP-1s long term, especially if they also have conditions such as diabetes, cardiovascular disease, obstructive sleep apnea, or metabolic dysfunction-associated steatohepatitis (MASH)
SASP (Senescence-Associated Secretory Phenotype) signaling begins declining as the source cells are eliminated Weeks 2-6: Tissue microenvironments improve as SASP-driven inflammation decreases
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