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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]
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For chronic plasticity enhancement or age-related cognitive decline studies, Dihexa's sustained upregulation of synaptic markers (PSD-95, synaptophysin) and dendritic spine density provides superior durability compared to Cerebrolysin's transient effects that plateau after 46 weeks
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