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These side effects can impact patient tolerability and adherence, potentially limiting the widespread adoption of these drugs in some individuals
It functions as a direct antioxidant through its thiol group, a substrate for glutathione peroxidase and glutathione S-transferase enzymes, and a regulator of protein function through S-glutathionylation
Its still not cheap, however, and isnt always covered by insurance
Doctors prescribe it for diabetes and obesity
130 SIRT1 deacetylates NF-B, inhibiting pro-inflammatory cytokines (IL-6, TNF-) while promoting anti-inflammatory cytokines (IL-10), 35 limiting Th17 and Tc activation and supporting overall immune balance
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