During a three-week treatment period, both Cagrilintide and salmon calcitonin (sCT), another amylin receptor agonist, produced an acute reduction in food intake in WT mice on day 1 by 53% and 42%, respectively, but not in RAMP1/3 KO mice
Biochim Biophys Acta 835: 441447
This is partly because the physical effects of long-term hypothyroidism can persist, and partly because fatigue makes it harder to stay active
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Weight regain is common after stopping a GLP-1 medication because hunger, cravings, and food noise may return as the medications effects diminish