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In 1997, a mouse study demonstrated that genetic ablation of Mc4r resulted in an obese phenotype, hyperphagia, and hyperinsulinemia (35)
Pizzimenti S, Ciamporcero E, Daga M, Pettazzoni P, Arcaro A, Cetrangolo G, et al
These havent been performed, though, perhaps because of this treatments downsides IV glutathione can be expensive, inconvenient and associated with potential side effects (bleeding, infection, blood clots, etc.)
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