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In the absence of evidence from RCTs, real-world studies on hard outcomes have compared several classes of glucose-lowering medications, including GLP-1RA, dipeptidyl-peptidase 4 inhibitors (DPP-4i), and sodium glucose cotransporter-2 inhibitors (SGLT2i)

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GLP-1s can slow gastric emptying, which may reduce the oral absorption of other medications, including oral HRT tablets

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Beta blockers, certain antidepressants, corticosteroids, and insulin can all slow the weight loss timeline

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