In addition, MOTS-c serves as a signal for mitochondrial contact with external entities, and our group has shown that serum and skeletal muscle MOTS-c levels and mRNA levels were significantly increased in mice engaged in 8 weeks of aerobic training compared to control mice
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Andres Splenser, MD, an endocrinologist at Memorial Hermann, who was not involved in this study, suggested that the link may have something to do with the relationship between mood and appetite, among other potential factors
Volek's recovery study (PMID 11788381) deliberately used a three-week loading period before its exercise challenge an acknowledgment that the first week is preparation, not payoff
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