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While the evidence is not yet definitive, some researchers suggest that long-term exposure to GLP-1 drugs could potentially influence the activity of the guts L-cells the cells responsible for producing natural GLP-1 and related hormones such as GLP-2, which helps maintain the integrity of the intestinal lining

The elimination half-life sits under 30 minutes, meaning the intact peptide clears from the body relatively quickly

GLP-1 medications should not be taken by people with a history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2

One important limitation across this research: it's difficult to separate the effects of the medication itself from the effects of weight loss and dietary change

An endocrinologist evaluates these factors and creates an individualized treatment plan that combines lifestyle interventions with evidence-based medications when appropriate