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Recently, there has been concern about the potential link between NAION and the use of certain weight loss medications, including Ozempic and other semaglutide injectables like those mentioned above

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These drugs have demonstrated great promise in helping people lose weight when lifestyle changes alone have failed to produce the intended effects

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Over the last few years, several regulatory authorities, such as the FDA and EMA, reported the incidence of mood alterations, depressive symptoms, and even suicidal thoughts with the use of GLP-1 receptor agonists during the pharmacovigilance surveillance process, which raises the issue of their psychiatric safety [13,14,15]

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In this review, we aimed (i) to summarize the important roles of RS in maintaining glucose homeostasis, fat metabolism, cholesterol levels, mineral absorption, and regulation in metabolic disorders, (ii) to discuss the conflicting results about the effects of RS on metabolic disorders and (iii) to analyze the possible reasons for the conflicting results

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