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The anabolic effects are dose-dependent and tissue-nonspecific: IGF-1 LR3 activates PI3K/Akt and MAPK/ERK pathways in myocytes, adipocytes, chondrocytes, and hepatocytes simultaneously

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Violante S, Ijlst L, Te Brinke H, Koster J, Tavares de Almeida I, Wanders RJA, et al

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